The First Tiberium War

In the First Tiberium War the Brotherhood first launched an expansive campaign that eventually allowed it to take over most of Africa and launch a second campaign in mainland Europe. When GDI managed to take the initiative, to gain more support, Kane devised a plan to blame GDI for the slaughtering of the population of BiałystokPoland. Afterwards, Nod broadcast a fake news report claiming that GDI soldiers razed the whole town on suspicions of the citizens being involved in Tiberium smuggling.

The broadcast created a scandal that forced the United Nations Security Council to cut GDI funding pending an investigation, causing the GDI to apparently almost shut down. Kane however was unaware that this 'scandal' was used by GDI and the UN, and as Nod forces arrived they encountered heavy resistance from "abandoned" bases. Since the incursions into GDI territory caused Nod forces to be spread very thin, GDI not only repelled the attacks, but took large areas of Nod territory during their counterstrikes, giving them the decisive advantange in the first conflict.

Kane himself was believed to have been killed at the final stand of the Brotherhood near Sarajevo. With GDI forces closing in, Kane calmly attempted to exit his 'Temple of Nod' through the front door. However, as he gazed upon the ruined hallway the entire temple was suddenly bathed in the light of GDI's 
Ion Cannon. Kane was seemingly vapourised by the discharge, holding his arms out wide.